Urate urolithiasis in a 5‐week‐old Dalmatian with confirmed hereditary hyperuricosuria

Abstract A 5‐week‐old male Dalmatian was referred for suspected urethral obstruction. Imaging revealed multiple urinary bladder and urethral uroliths composed predominantly of ammonium urate. Genetic testing confirmed homozygosity for the SLC2A9 mutation associated with hereditary hyperuricosuria in this breed. The patient was managed conservatively with medical therapy, a balanced low‐purine diet formulated for growth, and regular monitoring. This case highlights the importance of including hereditary hyperuricosuria among the differential diagnoses for urate urolithiasis, even in very young dogs.

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Publication Details

Journal
Veterinary Record Case Reports
Published
2026-03-12
DOI
https://doi.org/10.1002/vrc2.70409
Primary Topic
Veterinary Medicine and Surgery
Type
article
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article

Urate urolithiasis in a 5‐week‐old Dalmatian with confirmed hereditary hyperuricosuria

M. Beccaglia, Martine Didier, Danilo Caristi, E. Fusi et al.
Veterinary Record Case Reports
Veterinary Medicine and Surgery
article

Urate urolithiasis in a 5‐week‐old Dalmatian with confirmed hereditary hyperuricosuria

M. Beccaglia, Martine Didier, Danilo Caristi, E. Fusi, Giulia Mangiagalli, Ginevra Riggio
article en

Abstract

Abstract A 5‐week‐old male Dalmatian was referred for suspected urethral obstruction. Imaging revealed multiple urinary bladder and urethral uroliths composed predominantly of ammonium urate. Genetic testing confirmed homozygosity for the SLC2A9 mutation associated with hereditary hyperuricosuria in this breed. The patient was managed conservatively with medical therapy, a balanced low‐purine diet formulated for growth, and regular monitoring. This case highlights the importance of including hereditary hyperuricosuria among the differential diagnoses for urate urolithiasis, even in very young dogs.

Veterinary Record Case ReportsVol. 14(2)
University of Milan (IT), Veterinary Oncological Center (IT), Centerforce (US)
Openalex Percentile: Top 23%
Veterinary Medicine and Surgery
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Urate urolithiasis in a 5‐week‐old Dalmatian with confirmed hereditary hyperuricosuria — M. Beccaglia, Martine Didier, et al. · Veterinary Record Case Reports (2026) | TGRS Research Map | TGRS