Promoter hypomethylation of CDH7: a novel epigenetic marker associated with cerebral small vessel disease
<i>CDH7</i> hypomethylation was identified and validated as an epigenetic marker predictive of MRI-defined SVD imaging features using blood inflammatory cells. This finding highlights the potential of epigenetic profiling for improving risk stratification in patients with cerebral SVD.
Authors
- Byoung‐Soo Shin (ORCID: https://orcid.org/0000-0002-3033-0014)
- Seong Hwan Ahn (ORCID: https://orcid.org/0000-0002-4778-491X)
- Hyeseon Jeong
- Jeeyeon Kim (ORCID: https://orcid.org/0000-0002-4818-4385)
- Jae Guk Kim
- K. Kang
- Jei Kim
- Hyun Goo Kang
- Do-Hyung Kim
- Young Ho Lee
- Jihye Park
- Dong-Ick Shin
- Dae-Hyun Kim
- Kyu Sun Yum
- Hee-Yun Chae
Institutions
- Chungbuk National University (KR)
- Chungnam National University (KR)
- Eulji University (KR)
- Dong-A University Hospital (KR)
- Chosun University Hospital (KR)
- Jeonbuk National University Hospital (KR)
- Chungnam National University Hospital (KR)
- Chungbuk National University Hospital (KR)
- Dankook University (KR)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fgene.2026.1780415
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yuhan
- Chungnam National University
- Chungnam National University Hospital