HKDC1-Mediated Polyamine Rewiring Drives Lenvatinib Resistance and Immune Escape in Hepatocellular Carcinoma
A USF1/HKDC1/SMS axis couples polyamine metabolism to immune dysfunction and lenvatinib resistance. HKDC1 is a predictive biomarker and therapeutic node and support polyamine-axis modulation to sensitize HCC to lenvatinib plus PD-1 therapy.
Authors
- Jing Cai (ORCID: https://orcid.org/0000-0003-3609-4291)
- P Zhang
- Jun Du (ORCID: https://orcid.org/0000-0002-9967-945X)
- Yufan Cai
- Jun Wan (ORCID: https://orcid.org/0000-0002-8273-8839)
- Guiqi Zhu
- Yujie Shao (ORCID: https://orcid.org/0009-0002-8594-6454)
- Biao Wang
- Shiping Chen
- Yi Yang
- Bing Quan
- Lina Song
- Zhi Dai
- Yang Zhang
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical and Molecular Hepatology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3350/cmh.2025.1269
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bethune Charitable Foundation
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality