PU.1: the conductor of Alzheimer’s symphony

A recent study by Ayata et al. (2025) reveals that the transcription factor PU.1 acts as a molecular switch that determines whether microglia protect against or worsen Alzheimer’s disease pathology, with lower PU.1 levels promoting beneficial microglial states that reduce amyloid burden and neuroinflammation.

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Publication Details

Journal
Molecular Neurodegeneration
Published
2026-03-13
DOI
https://doi.org/10.1186/s13024-026-00937-1
Primary Topic
Music Therapy and Health
Type
article
Field-Weighted Citation Impact
0.00
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article

PU.1: the conductor of Alzheimer’s symphony

Qianjin Liu, Chunli Sun
Molecular Neurodegeneration
Music Therapy and Health
article

PU.1: the conductor of Alzheimer’s symphony

Qianjin Liu, Chunli Sun
article en

Abstract

A recent study by Ayata et al. (2025) reveals that the transcription factor PU.1 acts as a molecular switch that determines whether microglia protect against or worsen Alzheimer’s disease pathology, with lower PU.1 levels promoting beneficial microglial states that reduce amyloid burden and neuroinflammation.

Molecular Neurodegeneration
Xuzhou Medical College (CN)
Openalex Percentile: Top 32%
Music Therapy and Health
DOIOpen Access PDFOpenAlex
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PU.1: the conductor of Alzheimer’s symphony — Qianjin Liu, Chunli Sun · Molecular Neurodegeneration (2026) | TGRS Research Map | TGRS