Relationship between <scp>hTERT</scp> levels and oxidative stress in epilepsy patients

We measured the levels of a protective protein that helps preserve chromosomes and several markers of cell stress in people with epilepsy and healthy volunteers. People with epilepsy showed lower levels of this protective protein, weaker antioxidant defenses, and higher oxidative stress. We also found that lower protein levels were linked to fewer molecules that guard cells from damage. These changes may help explain why seizures occur and why the brain can suffer ongoing injury in epilepsy.

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Publication Details

Journal
Epilepsia Open
Published
2026-03-12
DOI
https://doi.org/10.1002/epi4.70165
Primary Topic
Telomeres, Telomerase, and Senescence
Type
article
Field-Weighted Citation Impact
0.00
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article

Relationship between hTERT levels and oxidative stress in epilepsy patients

Deniz Tuncel Berktaş, Nuray Üremiş, Muhammed Mehdi Üremi̇ş, Fatma İnanç Tolun
Epilepsia Open
Telomeres, Telomerase, and Senescence
article

Relationship between hTERT levels and oxidative stress in epilepsy patients

Deniz Tuncel Berktaş, Nuray Üremiş, Muhammed Mehdi Üremi̇ş, Fatma İnanç Tolun
article en

Abstract

We measured the levels of a protective protein that helps preserve chromosomes and several markers of cell stress in people with epilepsy and healthy volunteers. People with epilepsy showed lower levels of this protective protein, weaker antioxidant defenses, and higher oxidative stress. We also found that lower protein levels were linked to fewer molecules that guard cells from damage. These changes may help explain why seizures occur and why the brain can suffer ongoing injury in epilepsy.

Epilepsia Open
Kahramanmaraş Sütçü İmam University (TR)
Openalex Percentile: Top 23%
Telomeres, Telomerase, and Senescence
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