Differential effects of non-selective and cardio-selective beta-blocker therapy on ECG parameters in long QT syndrome type 1
•Non-selective β-blockers markedly reduce Tpeak/end in LQT1 patients.•Cardio-selective β-blockers show no consistent effect on Tpeak/end.•The nsBB effect persists after exercise, independent of heart rate.•Tpeak/end shortening indicates decreased global repolarization heterogeneity and reduced arrhythmic risk.•Tpeak/end may serve as a novel ECG marker for β-blocker efficacy in LQT1.
Authors
- Vanessa Christe
- Saranda Nimani (ORCID: https://orcid.org/0000-0002-9298-3678)
- Marina Rieder (ORCID: https://orcid.org/0000-0002-3388-4119)
- Rachel Ma Ter Bekke
- Peter M. Deissler
- Katja E. Odening
Institutions
- Maastricht University Medical Centre (NL)
- University Hospital of Bern (CH)
- Maastricht University (NL)
- ERN GUARD-Heart (NL)
Publication Details
- Journal
- IJC Heart & Vasculature
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1016/j.ijcha.2026.101901
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00