Effects of Antibiotics and Anti-Inflammatory Drugs on Enamel Development: A Systematic Review with Quantitative Synthesis
This systematic review synthesizes experimental evidence on the biological vulnerability of developing enamel to pharmacological exposure, highlighting potential mechanisms underlying enamel thinning and hypomineralization while underscoring the need for cautious interpretation when extrapolating animal data to human clinical contexts. PROSPERO Registration No.: CRD42025606606.
Authors
- Bennett T. Amaechi (ORCID: https://orcid.org/0000-0002-5097-4466)
- Hien Chi Ngo
- Saniya Khani
- Nadia Zamri
- Kausar Sadia Fakhruddin
- Lakshman Samaranayake
- Elizabeth Court
Institutions
- Queensland Health (AU)
- The University of Texas at San Antonio Health Science Center (US)
- The University of Western Australia (AU)
- Los Medanos College (US)
- Royal Brisbane and Women's Hospital (AU)
- Dr. D.Y. Patil Vidyapeeth, Pune (IN)
- The University of Texas at San Antonio (US)
- University of Hong Kong (HK)
Publication Details
- Journal
- International Dental Journal
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1016/j.identj.2026.109478
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00