Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma
Our study establishes plasma EV-derived LOX as a promising non-invasive biomarker for LUAD-BrM through a comprehensive multi-omics validation strategy. We propose a model wherein downregulation of LOX, potentially driven by PI3K/AKT signaling in tumor-associated fibroblasts, contributes to ECM degradation and may promote brain-tropic metastasis. This finding offers new insights for risk stratification and timely intervention in LUAD patients.
Authors
- Cong-Ting Wu
- Yi Liu (ORCID: https://orcid.org/0000-0003-1635-4105)
- Jun Zhou (ORCID: https://orcid.org/0009-0000-2512-9036)
- Ju Li (ORCID: https://orcid.org/0000-0002-7841-8058)
- Yu Pei (ORCID: https://orcid.org/0000-0002-3709-1853)
- Jia-Li Sun
- Han-Xue Yang
- Xingjie Hao
- Wei Gong
- Yang Yao
- Fen Hu
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei University of Arts and Science (CN)
- Xiangyang Central Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1186/s12916-026-04785-0
- Primary Topic
- Microbial metabolism and enzyme function
- Type
- article
- Field-Weighted Citation Impact
- 0.00