Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer
The findings herein demonstrated that mitochondrial uncouplers inhibit MSCP through FTO-dependent m<sup>6</sup>A demethylation. This work identified mitochondrial uncoupling as a novel and promising therapeutic approach for promoting m<sup>6</sup>A demethylation and targeting MSCP in metastatic breast cancer.
Authors
- Erinn B. Rankin (ORCID: https://orcid.org/0000-0002-2045-2296)
- Meng-Ning Zhou (ORCID: https://orcid.org/0000-0001-8885-6089)
- Stavros Melemenidis (ORCID: https://orcid.org/0000-0002-3941-8784)
- Jiangbin Ye (ORCID: https://orcid.org/0000-0003-1117-4869)
- Michaela Yip (ORCID: https://orcid.org/0000-0002-7637-2746)
- Cathyrin Simmermaker
- Yiren Xiao (ORCID: https://orcid.org/0000-0003-3804-3383)
- Subarna Sinha
- Albert M. Li
- Daniel J. Cuthbertson
- Scott Jackson
- Man Zhao
- Xin Jin
- Yanan Yang
- Haowen Jiang
Institutions
- Agilent Technologies (United States) (US)
- Second Affiliated Hospital of Jilin University (CN)
- Stanford University (US)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2026-03-12
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0444
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Memorial Sloan-Kettering Cancer Center
- Stanford Maternal and Child Health Research Institute