Distinct gene expression profiles in blood–brain barrier capillary endothelial cells between mice and humans
Our cross-species in-depth analysis reveals both broad conservation and distinct transcriptomic differences between human and mouse BBB capillary ECs. Together, our findings provide a valuable framework for interpreting mouse BBB data in a translational context and for guiding future studies of endothelial biology in the human brain.
Authors
- Yuyang Miao (ORCID: https://orcid.org/0000-0001-8859-2992)
- Liqun He
- Weihan Li
- Maarja Andaloussi Mäe
- Lars Muhl
- Jianhao Wang
- Marie Jeansson
Institutions
- Zhejiang Chinese Medical University (CN)
- Uppsala University (SE)
- Tianjin Medical University General Hospital (CN)
- Karolinska Institutet (SE)
- Integrated Cardio Metabolic Centre (SE)
Publication Details
- Journal
- Microvascular Research
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1016/j.mvr.2026.104933
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00