Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence—The Protective Effect of Valsartan
These findings suggest that cellular senescence contributes to Tac-induced microvascular injury and hypertension and demonstrate the effectiveness of senolytic treatment for protection. Valsartan could reduce senescence indirectly by lowering blood pressure; a direct anti-senescence effect might also play a role in this context.
Authors
- Yunxiu Xiang
- Pontus Börje Persson (ORCID: https://orcid.org/0000-0003-0926-2878)
- Zhihua Zheng (ORCID: https://orcid.org/0000-0001-9312-5846)
- Gensheng Zhang (ORCID: https://orcid.org/0000-0002-8157-6460)
- Yangyang Zhang (ORCID: https://orcid.org/0000-0003-2549-8282)
- Pratik H. Khedkar (ORCID: https://orcid.org/0000-0002-4778-7731)
- Nan Xu (ORCID: https://orcid.org/0000-0003-1212-7773)
- Andreas Reinhold Patzak (ORCID: https://orcid.org/0000-0002-1088-6875)
- Enyin Lai (ORCID: https://orcid.org/0000-0003-3074-6869)
- Li Lü (ORCID: https://orcid.org/0000-0002-3794-2793)
- Xiaohua Wang (ORCID: https://orcid.org/0000-0002-6551-151X)
- J. Tang (ORCID: https://orcid.org/0000-0002-2926-2560)
- Junxuan Fang
- Jin Wei (ORCID: https://orcid.org/0000-0002-3236-9254)
- Yan Lei
- Dongliang Zhao
- Xun Qiu
- Kongyang Ma
- Lingyi Kong
- Lingyan Fei
- Liang Zhao
- Shan Jiang
- Yulin Liang
- Tianjiao Cui
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Sun Yat-sen University (CN)
- Henan University (CN)
- Humboldt-Universität zu Berlin (DE)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- City University of Hong Kong, Shenzhen Research Institute (CN)
- Children's Hospital of Zhejiang University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Institut de Recherche et d’Innovation (FR)
- Zhejiang University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1111/apha.70189
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 32.84
Funders
- National Natural Science Foundation of China
- Shenzhen Science and Technology Innovation Program