TSPO governs bone-lipid homeostasis by redirecting BMSC differentiation via the PI3K/AKT/β-catenin pathway
Our study identifies TSPO as a key pathogenic regulator that impairs osteogenesis by disrupting the PI3K/AKT/β-catenin pathway. Targeting TSPO presents a novel anabolic strategy for osteoporosis, potentially addressing the unmet clinical need for therapies that restore bone formation.
Authors
- Rongsheng Zhang (ORCID: https://orcid.org/0009-0008-1248-2090)
- Hanhao Dai (ORCID: https://orcid.org/0000-0002-8197-3183)
- Linhai Yang
- Hongyu Y. Zheng (ORCID: https://orcid.org/0000-0002-4895-0617)
- M. Zhang (ORCID: https://orcid.org/0000-0001-8659-5727)
- Jun Luo (ORCID: https://orcid.org/0000-0002-5122-6806)
- Chao Song (ORCID: https://orcid.org/0000-0002-8200-7673)
- Yibin Su
- Fenqi Luo
- Peng Zhang
- Jie Xu
- Zhibo Deng
- Guoyu Yu
- Zhao Lin
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Fujian Medical University (CN)
- Hubei University of Arts and Science (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s13287-026-04948-z
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00