Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study

We describe differences in kidney outcomes and BPD by sex. Male sex is associated with an increased risk of AKI and hypertension. Research efforts focused on the mechanisms underlying sex-specific differences are needed for the identification of novel therapies that benefit both sexes.

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Publication Details

Journal
Pediatric Nephrology
Published
2026-03-12
DOI
https://doi.org/10.1007/s00467-025-07131-3
Primary Topic
Pregnancy and Medication Impact
Type
article
Field-Weighted Citation Impact
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article

Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study

Michelle C. Starr, Krithika Lingappan, Matt Gillen, Shina Menon et al.
Pediatric Nephrology
Pregnancy and Medication Impact
article

Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study

Michelle C. Starr, Krithika Lingappan, Matt Gillen, Shina Menon, David J. Askenazi, Heidi J. Steflik, Danielle E. Soranno, David T. Selewski, Cara L. Slagle, Russell Griffin
article en

Abstract

We describe differences in kidney outcomes and BPD by sex. Male sex is associated with an increased risk of AKI and hypertension. Research efforts focused on the mechanisms underlying sex-specific differences are needed for the identification of novel therapies that benefit both sexes.

Pediatric Nephrology
Indiana University Health (US), Children's Hospital of Philadelphia (US), Emory University (US), Medical University of South Carolina (US), Purdue University West Lafayette (US), University of Alabama at Birmingham (US), Pediatric Nephrology of Alabama (US), Indiana University – Purdue University Indianapolis (US), University of Arkansas for Medical Sciences (US), Stanford University (US)
Openalex Percentile: Top 28%
Pregnancy and Medication Impact
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