Electrophotochemical Decarboxylative C−H Fluoroalkylation via a Fe <sub>2</sub> O <sub>3</sub> −FTO Active Photoanode
C−H fluoroalkylation of heteroarenes and biomolecules employing inexpensive carboxylic acids based on electrophotochemical oxidation on a Fe2O3 photoanode was developed. Notably, the devised approach proved amenable to a wide range of versatile late-stage C−H fluoroalkylations of biorelevant heterocycles. Mechanistic studies supported a direct electron transfer to form a fluoroalkyl radical with a cost-efficient heterogeneous iron catalyst.
Authors
- Vladimir Motornov (ORCID: https://orcid.org/0000-0002-4951-8113)
- Kentaro Imaoka
- Sven Trienes (ORCID: https://orcid.org/0009-0008-8910-7459)
- H. Kang
- Prof. Dr. Lutz Ackermann
- Zhi Liu (ORCID: https://orcid.org/0009-0000-0998-9546)
- R. Thomas Weitz
Institutions
- German Centre for Cardiovascular Research (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- ACS Catalysis
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1021/acscatal.5c07973
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00