Population pharmacokinetics and Monte Carlo simulation of Cefepime in paediatric and Young adult bone marrow transplant patients
This study presents the first cefepime PopPK model tailored to paediatric and young adult BMT recipients, identifying eGFR<sub>cr-cys</sub> as a key determinant of cefepime clearance. Prolonging the infusion duration or shortening the dosing interval may be required to enhance target attainment with initial dosing regimens. This PopPK model provides a foundation for individualized dosing adjustments through model-informed precision dosing.
Authors
- Tomoyuki Mizuno (ORCID: https://orcid.org/0000-0002-8471-9826)
- Stefanie W. Benoit (ORCID: https://orcid.org/0000-0002-4203-1978)
- Sonya Tang Girdwood
- Ronaldo Morales Junior
- Graham Klink
- H. Rhodes Hambrick
Institutions
- Northwestern University (US)
- Cincinnati Children's Hospital Medical Center (US)
- Lurie Children's Hospital (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1002/bcp.70519
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00