Electrochemical Iodine‐Catalyzed C(sp <sup>3</sup> )–H Amination for the Synthesis of 2‐Arylquinazolines

An efficient electrochemical C(sp 3 )–H amination cyclization was developed under mild conditions in the presence of an iodine catalyst. A series of substituted quinazolines can be obtained with good yields by virtue of the new avenue. The reaction features excellent substrate applicability, scalability, metal‐free, and chemical oxidant‐free.

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Publication Details

Journal
European Journal of Organic Chemistry
Published
2026-03-11
DOI
https://doi.org/10.1002/ejoc.202501224
Primary Topic
Quinazolinone synthesis and applications
Type
article
Field-Weighted Citation Impact
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article

Electrochemical Iodine‐Catalyzed C(sp 3 )–H Amination for the Synthesis of 2‐Arylquinazolines

Yupu Zhang, Hao Yang, Zhiyong Wang, Kai Li et al.
European Journal of Organic Chemistry
Quinazolinone synthesis and applications
article

Electrochemical Iodine‐Catalyzed C(sp 3 )–H Amination for the Synthesis of 2‐Arylquinazolines

Yupu Zhang, Hao Yang, Zhiyong Wang, Kai Li, Qi Sun
article en

Abstract

An efficient electrochemical C(sp 3 )–H amination cyclization was developed under mild conditions in the presence of an iodine catalyst. A series of substituted quinazolines can be obtained with good yields by virtue of the new avenue. The reaction features excellent substrate applicability, scalability, metal‐free, and chemical oxidant‐free.

European Journal of Organic Chemistry
University of Science and Technology of China (CN), Hefei National Center for Physical Sciences at Nanoscale (CN)
Openalex Percentile: Top 23%
Quinazolinone synthesis and applications
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