10-year experience in the use of Intravenous Immunoglobulin for Autoimmune Retinopathy

Autoimmune retinopathies which broadly overlap cancer associated retinopathy and non-paraneoplastic autoimmune retinopathy (npAIR) are complex diagnoses with visually devastating consequences [1].There is no consensus on systemic immunosuppression, though a recent meta-analysis of case reports has suggested benefit [2].We have seen limited response to classical immunosuppression in our practice and so have historically offered treatment with intravenous immunoglobulin (IVIg) which is commissioned in the UK, and here report on a cohort starting treatment over a 10-year period.Testing for anti-retinal antibodies (ARAb) was performed in all 18 patients but even in those that were negative (5/18), if a

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Publication Details

Journal
Eye
Published
2026-03-12
DOI
https://doi.org/10.1038/s41433-026-04368-6
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

10-year experience in the use of Intravenous Immunoglobulin for Autoimmune Retinopathy

Lina Kobayter, Rebecca Baker, A. Abraham, Anthony G. Robson et al.
Eye
Autoimmune Neurological Disorders and Treatments
article

10-year experience in the use of Intravenous Immunoglobulin for Autoimmune Retinopathy

Lina Kobayter, Rebecca Baker, A. Abraham, Anthony G. Robson, Chrysanthi Tsika, Colin J. Chu, Ester Carreño, Ian Yeung, Carlos E. Pavesio, Andrew D. Dick
article en

Abstract

Autoimmune retinopathies which broadly overlap cancer associated retinopathy and non-paraneoplastic autoimmune retinopathy (npAIR) are complex diagnoses with visually devastating consequences [1].There is no consensus on systemic immunosuppression, though a recent meta-analysis of case reports has suggested benefit [2].We have seen limited response to classical immunosuppression in our practice and so have historically offered treatment with intravenous immunoglobulin (IVIg) which is commissioned in the UK, and here report on a cohort starting treatment over a 10-year period.Testing for anti-retinal antibodies (ARAb) was performed in all 18 patients but even in those that were negative (5/18), if a

Eye
Moorfields Eye Hospital NHS Foundation Trust (GB), University Hospitals Bristol NHS Foundation Trust (GB), University of Bristol (GB), NIHR Moorfields Biomedical Research Centre (GB), Bristol Eye Hospital (GB), UK Dementia Research Institute (GB), Moorfields Eye Hospital (GB), University College London (GB)
NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, National Institute for Health and Care Research, Department of Health and Social Care, Moorfields Eye Hospital NHS Foundation Trust
Zero hunger, Good health and well-being
Openalex Percentile: Top 32%
Autoimmune Neurological Disorders and Treatments
DOIOpen Access PDFOpenAlex
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