The Hypoxostat Model: A Conceptual Framework Linking Hypoxia, Oxidative Stress and Periodontal Breakdown Under Orthodontic Load

Hypoxia and redox signaling function as a bistable regulatory system controlling bone and periodontal remodeling. The Hypoxostat Model provides a unifying framework linking oxygen tension, ROS dynamics, inflammatory cytokines, and remodeling outcomes. Recognizing hypoxia-reoxygenation behavior as a mechanistic switch may improve prediction of tissue vulnerability and guide therapeutic strategies aimed at modulating redox balance or enhancing local perfusion.