Lipidomic profiling in metastatic prostate cancer captures tumor metabolic rewiring and its modulation by androgen receptor–targeting therapy
Plasma lipidomics reflects key metabolic features of PCa and is profoundly impacted by AR inhibition, with prognostic relevance in patients with mCRPC. These findings support its potential as a non-invasive tool for monitoring disease activity and treatment response, and lay the groundwork for lipid-based biomarkers in mCRPC, while indicating that the lipidomic alterations observed may help inform ongoing and forthcoming research on metabolic targeting.
Authors
- Filippo Pederzoli (ORCID: https://orcid.org/0000-0003-3873-7465)
- David M. Nanus (ORCID: https://orcid.org/0000-0003-3514-2976)
- Salvatore Luca Burgio
- Cristian Lolli (ORCID: https://orcid.org/0000-0003-0347-9179)
- Hubert Pakula (ORCID: https://orcid.org/0000-0003-0070-3913)
- Giorgia Gurioli (ORCID: https://orcid.org/0000-0003-4036-5568)
- Lisa M. Butler (ORCID: https://orcid.org/0000-0003-2698-3220)
- Pier Vitale Nuzzo (ORCID: https://orcid.org/0000-0002-5618-8079)
- Giuseppe Schepisi (ORCID: https://orcid.org/0000-0002-9973-4869)
- Alessandra Virga (ORCID: https://orcid.org/0000-0001-9427-3875)
- Sara Bleve (ORCID: https://orcid.org/0009-0008-2704-1423)
- Nicole Brighi (ORCID: https://orcid.org/0000-0002-1187-5481)
- Emilio Francesco Giunta (ORCID: https://orcid.org/0000-0002-5383-4469)
- Francesco Ravera (ORCID: https://orcid.org/0000-0003-3856-7910)
- Giuseppe Nicolo’ Fanelli
- Silvia Rodrigues
- Johannes V. Swinnen
- Ugo De Giorgi
- Massimo Loda
Institutions
- University of Pisa (IT)
- Cornell University (US)
- Nuffield Orthopaedic Centre (GB)
- Lander Institute (IL)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Dana-Farber Cancer Institute (US)
- South Australian Health and Medical Research Institute (AU)
- Centre for Cancer Biology (AU)
- Ospedale Vito Fazzi (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- Weill Cornell Medicine (US)
- University of Genoa (IT)
Publication Details
- Journal
- Prostate Cancer and Prostatic Diseases
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1038/s41391-026-01100-z
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Prostate Cancer Foundation
- Associazione Italiana per la Ricerca sul Cancro