Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer
The ASCL1/LHX8 methylation test detects nearly all cancers and a majority of CIN3 in first-void urine, supporting the potential of full molecular screening in urine by primary HPV testing and methylation triage.
Authors
- Gilbert Donders (ORCID: https://orcid.org/0000-0001-9890-6254)
- Ann Cornelis
- Harold R Verhoeve (ORCID: https://orcid.org/0000-0002-0107-1148)
- Steven Weyers (ORCID: https://orcid.org/0000-0003-2828-8037)
- Annemie De Smet
- Laura Téblick (ORCID: https://orcid.org/0000-0002-7484-0956)
- Alex Vorsters (ORCID: https://orcid.org/0000-0002-0265-058X)
- Constantijne H. Mom (ORCID: https://orcid.org/0000-0003-2838-2031)
- Severien Van Keer (ORCID: https://orcid.org/0000-0003-1842-7478)
- Rianne van den Helder (ORCID: https://orcid.org/0000-0003-4422-7381)
- Chris J. L. M. Meijer
- Birgit I Lissenberg-Witte
- Renske D. M. Steenbergen
- Katty Delbecque
- Nienke van Trommel
- Koen Van de Vijver
- Maaike Bleeker
- Jean Doyen
Institutions
- Ghent University Hospital (BE)
- Antwerp University Hospital (BE)
- OLVG (NL)
- Infectious Diseases Institute (UG)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- Hospital zum Heiligen Geist (DE)
- Amsterdam University Medical Centers (NL)
- Amsterdam University of Applied Sciences (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1038/s43856-026-01512-x
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Fonds Wetenschappelijk Onderzoek
- Universiteit Antwerpen
- Vlaamse regering
- Eurostars