Streamlined artificial intelligence triage: CT imaging alone predicts neurosurgical need in traumatic brain injury

Timely surgical intervention is often critical in managing acute traumatic brain injury (TBI). Artificial intelligence (AI) may support triage by predicting neurosurgical need, especially where specialist expertise is lacking. While multimodal models that combine imaging and clinical data are often thought to improve performance, they also increase data acquisition complexity. This study evaluated whether multimodal AI models outperform unimodal models in predicting neurosurgical intervention for TBI. 3442 total patients presenting with a TBI were used in this research. Patients were split into two distinct datasets, a development dataset, and a holdout test dataset. The development dataset consisted of 2,928 adult trauma patients with CT and clinical data and was used to develop three models: clinical-only, imaging-only, and combined. Performance was assessed on the holdout test dataset of 514 patients. The clinical model achieved an AUC of 0.68 [0.64–0.73], the imaging model 0.86 [0.82–0.89], and the combined multimodal model 0.89 [0.86–0.92]. The combined model did not significantly outperform the image-only model. Given minimal gain and added complexity, image-based AI may offer a simpler, equally effective triage solution for TBI.

Authors

Institutions

Publication Details

Journal
Informatics in Medicine Unlocked
Published
2026-03-12
DOI
https://doi.org/10.1016/j.imu.2026.101749
Primary Topic
Traumatic Brain Injury and Neurovascular Disturbances
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Streamlined artificial intelligence triage: CT imaging alone predicts neurosurgical need in traumatic brain injury

François Mathieu, Alun Ackery, Eva Y. Yuan, Errol Colak et al.
Informatics in Medicine Unlocked
Traumatic Brain Injury and Neurovascular Disturbances
article

Streamlined artificial intelligence triage: CT imaging alone predicts neurosurgical need in traumatic brain injury

François Mathieu, Alun Ackery, Eva Y. Yuan, Errol Colak, Husain Shakil, Christopher W. Smith, Avery B. Nathens, Christopher Lozano, Christopher D. Witiw, Armaan K. Malhotra
article en

Abstract

Timely surgical intervention is often critical in managing acute traumatic brain injury (TBI). Artificial intelligence (AI) may support triage by predicting neurosurgical need, especially where specialist expertise is lacking. While multimodal models that combine imaging and clinical data are often thought to improve performance, they also increase data acquisition complexity. This study evaluated whether multimodal AI models outperform unimodal models in predicting neurosurgical intervention for TBI. 3442 total patients presenting with a TBI were used in this research. Patients were split into two distinct datasets, a development dataset, and a holdout test dataset. The development dataset consisted of 2,928 adult trauma patients with CT and clinical data and was used to develop three models: clinical-only, imaging-only, and combined. Performance was assessed on the holdout test dataset of 514 patients. The clinical model achieved an AUC of 0.68 [0.64–0.73], the imaging model 0.86 [0.82–0.89], and the combined multimodal model 0.89 [0.86–0.92]. The combined model did not significantly outperform the image-only model. Given minimal gain and added complexity, image-based AI may offer a simpler, equally effective triage solution for TBI.

Informatics in Medicine UnlockedVol. 62
St. Michael's Hospital (CA), Sunnybrook Health Science Centre (CA), University of Toronto (CA), Health Sciences Centre (CA), Unity Health Toronto
Openalex Percentile: Top 32%
Traumatic Brain Injury and Neurovascular Disturbances
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.