Identification of a Key Hemagglutinin Mutation Mediating Antibody Escape in Influenza A(H1N1)pdm09 Viruses
K147N is identified as the critical mutation mediating C12H5 immune escape, and this mutation has emerged in 2023 circulating strains. This study provides important molecular targets and early warning mechanisms for broad-spectrum antibody optimization and influenza vaccine updates.
Authors
- Kaiyun Chen (ORCID: https://orcid.org/0000-0003-1974-9428)
- Wenping Xie (ORCID: https://orcid.org/0000-0002-3286-7704)
- Yiming Li (ORCID: https://orcid.org/0000-0002-6107-5618)
- Taijiao Jiang (ORCID: https://orcid.org/0000-0002-6071-0122)
- Weili Song
- Wenjun Song
- Chuan Wang
Institutions
- Xiamen University (CN)
- Huazhong University of Science and Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Viruses
- Published
- 2026-03-12
- DOI
- https://doi.org/10.3390/v18030349
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xiamen University