Mortality score in chronic coronary syndrome: prediction model from the ISCHEMIA trial
What we did and found: Using the randomized ISCHEMIA trial (5179 patients), we built a risk score from routinely available data-glomerular filtration rate, ST-segment depression and exercise duration on a stress test, systolic blood pressure, multivessel coronary disease, and initial treatment strategy (invasive vs. conservative). The score clearly separated lower- from higher-risk patients and showed strong discrimination. Its performance for all-cause death was confirmed in an independent, contemporary multicentre registry of over 23 000 patients with long-term follow-up. Why it matters for patients and clinicians: Because it relies on familiar information collected in everyday practice, ISCHEMIA-PREDICT can help clinicians quickly gauge mortality risk in chronic coronary syndrome patients and tailor care accordingly-supporting intensified medical therapy and consideration of invasive management in those at highest risk. A web calculator enables point-of-care use and risk-guided decision-making.
Authors
- Magdalena Mizia
- Bartosz Hudzik (ORCID: https://orcid.org/0000-0003-3880-5325)
- Eliano Pio Navarese (ORCID: https://orcid.org/0000-0002-2355-4589)
- Wojciech Wojakowski (ORCID: https://orcid.org/0000-0002-3681-5207)
- Michael E. Farkouh (ORCID: https://orcid.org/0000-0002-8095-0246)
- Julia M. Umińska (ORCID: https://orcid.org/0000-0003-2309-2369)
- GRZEGORZ SMOLKA
- Giuseppe Talanas (ORCID: https://orcid.org/0000-0003-4317-9728)
- Eric Van Belle
- D.J. Kereiakes
- Daniel Cieśla
- Z Kalarus
- Giuseppe Massimo Sangiorgi
- Jacek Kubica
- Antonio Buffon
- Mariusz Gąsior
- Timothy D Henry
- Felicita Andreotti
- Francesco Burzotta
- Ron Waksman
- Gregg W Stone
Institutions
- MedStar Washington Hospital Center (US)
- University of Sassari (IT)
- Medical University of Silesia (PL)
- Institut Pasteur de Lille (FR)
- Agostino Gemelli University Polyclinic (IT)
- Nicolaus Copernicus University (PL)
- University of Bydgoszcz (PL)
- Wojewódzki Szpital Specjalistyczny nr 4 w Bytomiu (PL)
- Silesian Center for Heart Disease (PL)
- Christ Hospital (US)
- Policlinico Tor Vergata (IT)
- Sinai Health System (US)
- Christ Hospital (US)
- Link Campus University (IT)
- Catholic University of America (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2026-02-17
- DOI
- https://doi.org/10.1093/eurjpc/zwag116
- Primary Topic
- Cardiac Health and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00