Systemic lupus erythematosus: one year in review 2026
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by a complex pathogenesis, heterogeneous clinical manifestations and a variable disease course. This review summarises the most relevant contributions on SLE published during 2025, following the framework of the One Year in Review series. In particular, we focus on emerging pathogenetic insights, novel and refined biomarkers, clinical manifestations and outcomes, comorbidities, and evidence from clinical trials and real-world studies, highlighting both recent progress and persistent unmet needs in the management of SLE.
Authors
- Dina Zucchi (ORCID: https://orcid.org/0000-0002-2161-2562)
- Angela Rita Elia (ORCID: https://orcid.org/0000-0002-0865-774X)
- Chiara Cardelli (ORCID: https://orcid.org/0000-0001-6407-6213)
- Elena Elefante (ORCID: https://orcid.org/0000-0003-0657-485X)
- Giancarlo Cascarano
- Ettore Silvagni (ORCID: https://orcid.org/0000-0001-7654-8222)
- Marco Oliva
- Alessandra Bortoluzzi
- Giorgia Capozzo
- Chiara Tani
Institutions
- University of Siena (IT)
- University of Pisa (IT)
- University of Ferrara (IT)
Publication Details
- Journal
- Clinical and Experimental Rheumatology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.55563/clinexprheumatol/mg0q41
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00