Dermatofibrosarcoma protuberans misdiagnosed as lipoma: a case report and literature review

Dermatofibrosarcoma protuberans (DFSP) is a relatively rare locally aggressive skin tumor. In its early stages, it can be easily confused with benign tumors such as lipomas and fibromas. Negative surgical margins represent the preferred treatment method for DFSP. For patients with advanced, unresectable disease, imatinib is a good option. The high rate of local recurrence remains a significant issue affecting patient prognosis. Here, we report on a case of a 30-year-old male patient with DFSP originating from the pubic symphysis. Due to the nonspecific clinical signs and the imaging findings, coupled with the rarity of DFSP and its location, the patient was misdiagnosed as having a lipoma and underwent surgical treatment. It was only through pathological examination that a diagnosis of DFSP was confirmed. This case emphasizes the importance of considering DFSP in the differential diagnosis of soft tissue masses, even in atypical locations.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-03-12
DOI
https://doi.org/10.3389/fonc.2026.1697836
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Dermatofibrosarcoma protuberans misdiagnosed as lipoma: a case report and literature review

Yuqin Wang, Feiyu Yin, Longguo Dai, Zhe Yang et al.
Frontiers in Oncology
Sarcoma Diagnosis and Treatment
article

Dermatofibrosarcoma protuberans misdiagnosed as lipoma: a case report and literature review

Yuqin Wang, Feiyu Yin, Longguo Dai, Zhe Yang, ChongJian Zhang, Xinghao Yang, Xusong Pang, Haiyang Jiang
article en

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a relatively rare locally aggressive skin tumor. In its early stages, it can be easily confused with benign tumors such as lipomas and fibromas. Negative surgical margins represent the preferred treatment method for DFSP. For patients with advanced, unresectable disease, imatinib is a good option. The high rate of local recurrence remains a significant issue affecting patient prognosis. Here, we report on a case of a 30-year-old male patient with DFSP originating from the pubic symphysis. Due to the nonspecific clinical signs and the imaging findings, coupled with the rarity of DFSP and its location, the patient was misdiagnosed as having a lipoma and underwent surgical treatment. It was only through pathological examination that a diagnosis of DFSP was confirmed. This case emphasizes the importance of considering DFSP in the differential diagnosis of soft tissue masses, even in atypical locations.

Frontiers in OncologyVol. 16
Kunming Medical University (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 24%
Sarcoma Diagnosis and Treatment
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