CMAISE: Establishing the Longitudinal Multi‐Omics Cohort for Sepsis Precision Medicine
ABSTRACT Sepsis remains a leading cause of mortality worldwide due to its profound biological heterogeneity. While multi‐omics approaches offer promise for precision medicine, existing datasets often lack longitudinal granularity or comprehensive clinical integration. We present the Chinese Multi‐omics Advances In Sepsis (CMAISE) cohort, a prospective, multicenter initiative integrating high‐resolution multi‐omics (transcriptomics, proteomics, metabolomics, and scRNA‐Req) with deep clinical phenotyping. By combining molecular trajectories with continuous vital signs and laboratory data, CMAISE provides an unprecedented resource to decode sepsis complexity. This correspondence outlines the cohort design, data resources, and its potential to accelerate the discovery of treatable traits.
Authors
- Qian Gao (ORCID: https://orcid.org/0000-0002-6906-1771)
- S-J Wu
- Haoran Chen (ORCID: https://orcid.org/0000-0002-8698-8712)
- Bing Tan (ORCID: https://orcid.org/0000-0001-7181-865X)
- Lvyin Yan
- Hongjun Kang
- Jun Cai (ORCID: https://orcid.org/0000-0002-5959-3264)
- Suibi Yang
- Ze Zhang (ORCID: https://orcid.org/0000-0001-9763-4592)
- Le Chen (ORCID: https://orcid.org/0000-0002-0382-5863)
- Fuhong Su (ORCID: https://orcid.org/0000-0002-6422-3727)
- Yao Yan (ORCID: https://orcid.org/0000-0001-8000-6952)
- Yuxin Leng (ORCID: https://orcid.org/0000-0002-9086-4835)
- Shuping Song
- Ruilan Wang
- Nan Wang (ORCID: https://orcid.org/0009-0001-3237-5339)
- Yang Wang (ORCID: https://orcid.org/0000-0002-5040-2492)
- Yiming Shao
- Songzan Qian
- Songqiao Liu
- Kun Cheng
- Bo Zhang
- Lina Xian
- Xinhao Jin
- Jie Yang
- Jingye Pan
- Zhihao Wang
- Kang Zou
- Jun Guo
- Changlin Sun
- Yi Yang
- Tianlong Zhang
- Dongdong Yang
- Caibao Hu
- Jinyan Xing
- Zhen Wang
Institutions
- Qingdao University (CN)
- Université Libre de Bruxelles (BE)
- Army Medical University (CN)
- Guangdong Medical College (CN)
- Shanghai Jiao Tong University (CN)
- Shaoxing University (CN)
- Peking University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Chinese PLA General Hospital (CN)
- The Fourth People's Hospital (CN)
- Daping Hospital (CN)
- Zhejiang Provincial Hospital of TCM (CN)
- Zhongda Hospital Southeast University (CN)
- Tongren Hospital (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- Zhejiang Hospital (CN)
- Guang Fu Hospital (CN)
- Dongguan People’s Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- Zhejiang Provincial People's Hospital (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
- Centre for Global Health Research (CA)
- Peking University Third Hospital (CN)
- Fujian Provincial Hospital (CN)
- Zhejiang Taizhou Hospital (CN)
- Jinhua Central Hospital (CN)
- University College London (GB)
- Imperial College London (GB)
- Zhejiang University (CN)
- Hainan Medical University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Med Research
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1002/mdr2.70057
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00