Asiaticoside attenuates renal fibrosis by targeting STAT3 to restore Th17/Treg homeostasis
AS alleviates RF via a novel "bind to destabilize" allosteric degradation mechanism that directly targets the STAT3 SH2 domain. This interaction induces conformational instability, suppresses STAT3 activation and transcriptional activity, restores Th17/Treg homeostasis, and ultimately mitigates renal inflammation and fibrosis. Collectively, these findings establish a new therapeutic strategy for STAT3-driven fibrotic diseases.
Authors
- Tao‐Tao Tang (ORCID: https://orcid.org/0000-0003-0220-3285)
- Wei-Jie Ni
- Wei Jiang (ORCID: https://orcid.org/0000-0002-1374-053X)
- Bo Wang (ORCID: https://orcid.org/0000-0003-4172-9271)
- Lijun Xie (ORCID: https://orcid.org/0000-0001-9016-7143)
- Sijie Chen (ORCID: https://orcid.org/0000-0002-5420-0804)
- Lin-Li Lv (ORCID: https://orcid.org/0009-0001-3330-1489)
- Y. Fu
- Qin Yang
- Hai-Feng Ni
- Bin Wang
- Yi Wen
- Yi-Lin Zhang
- Bi-Cheng Liu
- Qing Wei
Institutions
- Zhongda Hospital Southeast University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1016/j.phymed.2026.158049
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00