Emulsomes in dermatology: A review of therapeutic applications

Abstract: Skin disorders are widespread due to the large surface area of the skin and its continuous exposure to environmental factors. Conventional topical formulations often have limitations such as inadequate penetration, instability, and the need for repeated application, which has led to increasing interest in nanotechnology-based systems. Emulsomes, a class of lipid-based vesicles with a solid lipid core surrounded by a phospholipid bilayer, provide high drug entrapment, controlled release, and improved skin permeation. This review examines published literature from 2007 to 2025, retrieved from databases including PubMed, Science Direct, and Google Scholar, to evaluate the role of emulsomes in dermatological therapy. Studies indicate that emulsomes can improve treatment outcomes, extend drug retention in skin layers, reduce adverse effects, and enhance patient compliance when compared with conventional or other nanoformulations. They have been investigated for use in conditions such as psoriasis, acne, skin cancer, fungal infections, and inflammatory diseases. Emulsomes, therefore, offer a practical approach to overcoming many challenges of topical therapy and hold potential for further development as effective carriers in dermatology.