M2-type tumor-associated macrophages promote invasion of canine breast cancer through ADAM9 upregulation
These findings identify ADAM9 as a key effector of TAM-driven tumor invasion through ECM remodeling and cytoskeletal regulation, and highlight ADAM9 as a promising therapeutic target within the tumor immune microenvironment.
Authors
- Hui-Su Kim (ORCID: https://orcid.org/0000-0002-4789-4529)
- Je‐Yoel Cho (ORCID: https://orcid.org/0000-0003-1030-3577)
- Jeong-Woon Lee (ORCID: https://orcid.org/0000-0003-2419-2310)
- Fangrong Wu
Institutions
- Seoul National University (KR)
- Korea Institute of Brain Science (KR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1777860
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00