Beta cell glucose sensitivity identifies clinical response to disease-modifying therapies initiated at stage 3 type 1 diabetes onset

Our results identified thresholds of change in βGS associated with a clinically significant impact on glycaemic management after intervention and suggest that baseline βGS in association with clinical and demographic parameters may be applied to identify individuals who are more likely to respond to an intervention.

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Publication Details

Journal
Diabetologia
Published
2026-03-12
DOI
https://doi.org/10.1007/s00125-026-06703-8
Primary Topic
Diabetes and associated disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Beta cell glucose sensitivity identifies clinical response to disease-modifying therapies initiated at stage 3 type 1 diabetes onset

Andrea Mari, Carmella Evans-Molina, Stephen E. Gitelman, Ele Ferrannini
Diabetologia
Diabetes and associated disorders
article

Beta cell glucose sensitivity identifies clinical response to disease-modifying therapies initiated at stage 3 type 1 diabetes onset

Andrea Mari, Carmella Evans-Molina, Stephen E. Gitelman, Ele Ferrannini
article en

Abstract

Our results identified thresholds of change in βGS associated with a clinically significant impact on glycaemic management after intervention and suggest that baseline βGS in association with clinical and demographic parameters may be applied to identify individuals who are more likely to respond to an intervention.

Diabetologia
University of California, San Francisco (US), Istituto di Fisiologia Clinica (IT), Richard L. Roudebush VA Medical Center (US), Neuroscience Institute (IT), Indiana University – Purdue University Indianapolis (US)
National Institutes of Health, School of Medicine, Indiana University
Openalex Percentile: Top 24%
Diabetes and associated disorders
DOIOpen Access PDFOpenAlex
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