Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study
Sleep traits show distinct, partly independent causal links with aging: excessive napping adversely influences GrimAge and frailty; longer sleep duration independently protects against frailty; and chronotype benefits facial ageing and cognition after accounting for other sleep behaviors.
Authors
- H. Qiu
- Qinghua Luo
- Xinglian Wang
- Guang Yang
- Chenggang Jiang
- Zheng Zhang
Institutions
- Xuzhou Medical College (CN)
- Lianyungang Oriental Hospital (CN)
- Chongqing Maternal and Child Health Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1186/s13148-026-02068-2
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centre Scientifique et Technique du Bâtiment