Development of mass spectrometry‐based genotyping method for simultaneous detection of 35 <scp>HPA</scp> systems, 5 <scp>HNA</scp> systems and the <scp>CD36</scp> antigen

We successfully developed an MS panel capable of detecting all currently known HPAs, HNAs, and the CD36 antigen, overcoming limitations of previous methods related to non-specific HNA-1 amplification. This method also demonstrated its efficacy in establishing a large-scale platelet donor database, and rare allele data support precise transfusion matching for special patients.

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Publication Details

Journal
Transfusion
Published
2026-03-12
DOI
https://doi.org/10.1111/trf.70167
Primary Topic
Blood disorders and treatments
Type
article
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article

Development of mass spectrometry‐based genotyping method for simultaneous detection of 35 HPA systems, 5 HNA systems and the CD36 antigen

Ruishu Li, L. Ye, Min Fu, Qixiu Yang et al.
Transfusion
Blood disorders and treatments
article

Development of mass spectrometry‐based genotyping method for simultaneous detection of 35 HPA systems, 5 HNA systems and the CD36 antigen

Ruishu Li, L. Ye, Min Fu, Qixiu Yang, Qinqin Ma, Ping Lu, Ziyan Zhu, Huijun Zhu
article en

Abstract

We successfully developed an MS panel capable of detecting all currently known HPAs, HNAs, and the CD36 antigen, overcoming limitations of previous methods related to non-specific HNA-1 amplification. This method also demonstrated its efficacy in establishing a large-scale platelet donor database, and rare allele data support precise transfusion matching for special patients.

Transfusion
Shanghai Blood Center (CN)
Openalex Percentile: Top 24%
Blood disorders and treatments
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