The ALT FLOW early feasibility study 3-year results assessing left atrial to coronary sinus shunting in HFpEF
In patients with HF and LVEF >40%, the APTURE LA-to-CS shunting confirmed an acceptable safety profile with stable right heart parameters and sustained improvements in symptoms, quality of life, and functional capacity at 3 years. Observed survival and HFH were superior to MAGGIC predictions.
Authors
- Peter Eckman (ORCID: https://orcid.org/0000-0002-8915-1942)
- B. Hibbert
- R. Tedford
- Lillian Aldaia (ORCID: https://orcid.org/0000-0002-8656-8929)
- Emil Missov
- Francesco Fioretti (ORCID: https://orcid.org/0000-0001-7174-8604)
- Hirak Shah (ORCID: https://orcid.org/0000-0003-3866-7356)
- Bhanu Gupta (ORCID: https://orcid.org/0000-0001-5113-6707)
- Trevor Simard (ORCID: https://orcid.org/0000-0001-9465-8150)
- Konstantinos Koulogiannis (ORCID: https://orcid.org/0000-0002-5889-0865)
- Andrés M. Pineda (ORCID: https://orcid.org/0000-0002-9877-114X)
- Babak Nazer
- P Sorajja
- Andrew J Sauer
- William A Gray
- Firas Zahr
- Javed Butler
- Marino Labinaz
- Mark Wiley
Institutions
- Main Line Health (US)
- Abbott Northwestern Hospital (US)
- Allina Health (US)
- Medical University of South Carolina (US)
- University of Ottawa (CA)
- Oregon Health & Science University (US)
- Franciscan Health (US)
- University of Washington Medical Center (US)
- Morristown Medical Center (US)
- University of Florida (US)
- University of Mississippi (US)
- Lankenau Heart Institute (US)
- Mayo Clinic in Arizona (US)
- Duke Medical Center (US)
- University of Kansas Medical Center (US)
- Saint Luke's Hospital (US)
- Baylor Scott & White Health (US)
- Florida College (US)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-03-03
- DOI
- https://doi.org/10.1093/eschf/xvag070
- Primary Topic
- Cardiovascular and Diving-Related Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00