Perioperative Ketamine and Esketamine for Enhanced Recovery After Surgery (ERAS): A Systematic Review
Perioperative ketamine and esketamine are valuable adjuncts to ERAS multimodal analgesia, with evidence also supporting their effects on depressive and sleep disorders. However, evidence is limited by high heterogeneity, small sample sizes, underpower, inconsistent or non-standardized outcome assessment tools, and short follow-up durations. Optimal dosing strategies remain undetermined.
Authors
- Richard W. Rosenquist (ORCID: https://orcid.org/0000-0002-9067-9058)
- Lei Xu (ORCID: https://orcid.org/0000-0002-8499-0448)
- Ming Yao (ORCID: https://orcid.org/0009-0000-5660-4813)
- Yanan Sun (ORCID: https://orcid.org/0000-0003-4940-3743)
- Yong-jun She
- Xudong Han
- Rui Zhu (ORCID: https://orcid.org/0000-0001-7631-3589)
- Jijun Xu
- Muhan Xu
Institutions
- Cleveland Clinic (US)
- Nantong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Cleveland Clinic Lerner College of Medicine (US)
- Affiliated Hospital of Nantong University (CN)
- Jiaxing University (CN)
- First Hospital of Jiaxing (CN)
Publication Details
- Journal
- Journal of Investigative Surgery
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1080/08941939.2026.2637241
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00