Precision Design in Cancer Treatment: Cucurbitacin E Modulates AMPK, PGK1, and PKM2 to Optimize Radiation Efficacy in Melanoma
CE acts as a potent radiosensitizer, augmenting γ-irradiation-induced apoptosis in A375 cells through metabolic disruption, oxidative stress modulation, intrinsic apoptotic activation, and cell cycle arrest. These results highlight its potential for improving melanoma radiotherapy. Future research should optimize dosing regimens and explore clinical translation to advance precision oncology strategies.
Authors
- Sahera F. Mohamed (ORCID: https://orcid.org/0000-0002-5328-2182)
- Sylvia A. Boshra (ORCID: https://orcid.org/0000-0003-4059-2912)
- Ahmed Emara (ORCID: https://orcid.org/0009-0001-2718-8627)
- Ahmed Hamdy (ORCID: https://orcid.org/0000-0002-2087-4712)
- Ibrahim G. Abdelrhman (ORCID: https://orcid.org/0000-0003-1326-8180)
- Mohammed Abdalla Hussein
- Amira Atef Mahmoud
Institutions
- Al-Hussein Bin Talal University (JO)
- Higher Institute of Engineering (EG)
- October 6 University (EG)
- Jazan University (SA)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2026-03-11
- DOI
- https://doi.org/10.2174/0113816128418138251206141825
- Primary Topic
- Advances in Cucurbitaceae Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00