Heterogeneity and regulatory mechanisms of ALK-mutant and wild-type epithelial cells in non-small-cell lung cancer: Single-cell transcriptomics and chromatin accessibility
ALK mutations drive tumor stemness and drug resistance by blocking epithelial cell differentiation, activating CEACAM6-mediated signaling, enhancing chromatin accessibility, and remodeling the EGR1/PRC regulatory network. Targeting CEACAM6 and its downstream effector EGR1 may represent an effective strategy to overcome ALK-TKI resistance.
Authors
- Jianhua Yan
- Manni Yi
- Yafu Zhou
- Jingsong Yang
- Huiguo Chen
Publication Details
- Journal
- Pharmacology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1159/000550967
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00