ALA-PDT activates macrophage autophagy via the ROS-EP300 pathway to kill intracellular Mycobacteroides abscessus
These findings demonstrate that ALA-PDT activates antibacterial autophagy via the ROS-EP300 pathway to eliminate intracellular M. abscessus, uncovering a potential epigenetic immune mechanism. This work provides a theoretical foundation for the clinical application of ALA-PDT in treating M. abscessus infections.
Authors
- Zhenyu Kou
- Xia Lei (ORCID: https://orcid.org/0000-0002-7169-3487)
- Yongdong Dai (ORCID: https://orcid.org/0000-0002-5494-6948)
- Ji Zhong
- Yiting Feng
- Jiayi Chang
- Xiaoyu Wang
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Daping Hospital (CN)
- Shanghai Center For Bioinformation Technology (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1016/j.pdpdt.2026.105440
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00