NMD takes two PIN domains to tango
Three new studies (Arpa et al. 2026; Kurscheidt et al. 2026; Modena et al. 2026) found that the PIN domains of SMG5 and SMG6, two proteins involved in nonsense-mediated mRNA decay (NMD), interact and show that the physiological endonucleolytic activity initiating the degradation of the nonsense mRNA is exerted by this composite catalytic site.
Authors
- Evangelos D. Karousis (ORCID: https://orcid.org/0000-0002-0390-0181)
- Oliver Muhlemann
Institutions
- University of Bern (CH)
- Universidad Iberoamericana (DO)
Publication Details
- Journal
- RNA
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1261/rna.081027.126
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eidgenössische Technische Hochschule Zürich