Dual roles of GDNF in enteric glial cell plasticity: direct transdifferentiation via the CaMKII/NeuroD1 pathway and cooperative regulation in a neural stem cell-inducing medium
NSC-Med promotes stem cell-associated features and gene expression in enteric glial cells. GDNF-a key component of NSC-Med-activates a neurogenic cascade via the calcium signaling pathway (CaMKII-NeuroD1 axis), which offers a potential targeted molecular strategy for HSCR therapy.
Authors
- Hui Yu (ORCID: https://orcid.org/0000-0002-4617-7640)
- Donghao Tian (ORCID: https://orcid.org/0009-0007-5291-5201)
- Hanlei Yan
- Jie Huang (ORCID: https://orcid.org/0009-0001-1696-4694)
- Zihao Fu
- Wenyao Xu
- Wanying Jia
- Xinlin Chen
- Ya Gao
- Wei Liu
Institutions
- Luoyang Central Hospital Affiliated to Zhengzhou University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1186/s13287-026-04966-x
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00