Ubiquitin C-terminal hydrolase L3 promotes liver cancer cell proliferation by modulating the AMP-activated protein kinase signaling pathway
UCHL3 may negatively modulate the AMPK pathway and autophagy in liver cancer to maintain the expression of cell cycle regulators and facilitate cell proliferation. Targeting overexpressed UCHL3 may be feasible to inhibit liver cancer progression.
Authors
- Shimin Sun (ORCID: https://orcid.org/0000-0003-1263-5866)
- Baoshuai Wang Baoshuai Wang
- Hao Wang
- Bin Guo
- Tao Wu
- Yishen Li
- Yan Liu
- Jingbo Lu
- Xinyu Wang
Institutions
- China Pharmaceutical University (CN)
- Third Affiliated Hospital of Inner Mongolia Medical College (CN)
- State Key Laboratory of Natural Medicine
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1007/s00432-026-06452-6
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China