Integrating metabolomics and molecular dynamics simulation to elucidate the anti-atherosclerotic mechanisms of Gynostemma pentaphyllum
GP exerts anti-atherosclerotic effects through a multi-component, multi-target mechanism, with activation of the PPARγ-LXRα pathway and inhibition of NF-κB driven inflammation being central to its therapeutic action.
Authors
- Yuying Du (ORCID: https://orcid.org/0000-0001-7786-0541)
- Wentian Zong (ORCID: https://orcid.org/0000-0001-9511-0605)
- Wenyu Bu
- Shidian Zhu
- Fuming Liu
- Junwei Qiu
- Yinghong Xia
- Yanzi Liu
- Qiuyu Yu
- Zhirong Geng
- Xiaoling Huang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Yancheng Third People's Hospital (CN)
Publication Details
- Journal
- Archives of Biochemistry and Biophysics
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1016/j.abb.2026.110793
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00