FYN/LCK kinase balance as a metabolic switch orchestrates progenitor exhausted T Cell differentiation in hepatocellular carcinoma
This study establishes the balance between SRC kinases FYN and LCK as a critical regulator of the terminal exhaustion of Tpex cell through metabolic reprogramming. The finding suggests that modulating the FYN/LCK kinase balance is a promising strategy to overcome immunotherapy resistance in HCC.
Authors
- Zhiqiang Meng (ORCID: https://orcid.org/0000-0003-3593-6098)
- Ranna Yeerken
- Hor‐Yue Tan (ORCID: https://orcid.org/0000-0002-9338-2495)
- Hongchao Yuan (ORCID: https://orcid.org/0000-0001-6107-7851)
- Chien‐shan Cheng (ORCID: https://orcid.org/0000-0003-4885-6759)
- Yibin Feng (ORCID: https://orcid.org/0000-0002-0241-670X)
- Ping Lü (ORCID: https://orcid.org/0000-0002-4340-2670)
- Qiucheng Li (ORCID: https://orcid.org/0000-0002-6325-2438)
- Yau-Tuen Chan
- Rui Wang (ORCID: https://orcid.org/0000-0002-2629-4735)
- Zhuofeng Jiang
- Zixin Feng
- Junyu Wu
- Lin Xu
- Junbang Chen
Institutions
- Hong Kong Baptist University (HK)
- Chinese University of Hong Kong (HK)
- Fudan University Shanghai Cancer Center (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Hepatology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1097/hep.0000000000001740
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00