Genetic association between ABCG2 rs2231142 polymorphism and psoriasis risk in a Türkiye population

Aims: Psoriasis is a persistent, immune-mediated dermatological condition shaped by both hereditary and environmental influences. The ABCG2 gene, encoding an ATP-binding cassette transporter, is involved in processes such as cellular detoxification, urate handling, and modulation of inflammatory pathways. The rs2231142 single nucleotide polymorphism (G>T) in ABCG2, which reduces transporter efficiency, has been linked to several inflammatory diseases. This study sought to determine whether the rs2231142 variant is associated with psoriasis risk in a Turkish cohort.Methods: The study included 150 patients with psoriasis and 150 healthy individuals. Genotyping for rs2231142 was performed using the tetra-primer ARMS-PCR method. Data were evaluated under codominant, dominant, and allelic inheritance models.Results: A significant difference in rs2231142 genotype distribution was observed between cases and controls (TT vs. GG: OR = 1.89, 95% CI = 1.03–3.48; p = 0.040). In the dominant model (GT+TT vs. GG), the variant was also significantly related to higher psoriasis risk (OR = 1.77, 95% CI = 1.11–2.83; p = 0.017). The T allele occurred more frequently in patients (38.3%) compared to controls (27.3%), conferring increased risk (OR = 1.42, 95% CI = 1.05–1.90; adjusted p = 0.021). No statistically significant correlations were found between rs2231142 genotypes and clinical characteristics such as disease duration, Psoriasis Area and Severity Index (PASI) score, or positive family history.Conclusion: The rs2231142 polymorphism in ABCG2 appears to be associated with a greater likelihood of developing psoriasis, possibly due to reduced transporter activity and intensified inflammatory responses.