Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism
Among patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. (Funded by the Canadian Institutes of Health Research and others; COBRRA ClinicalTrials.gov number, NCT03266783.).
Authors
- Tim Ramsay
- Tobias Tritschler (ORCID: https://orcid.org/0000-0002-8775-0511)
- Vivien Chen (ORCID: https://orcid.org/0000-0001-5119-7470)
- Ritam Prasad
- Geneviève Le Templier
- Fionnuala Ní Áinle (ORCID: https://orcid.org/0000-0003-0163-792X)
- Etimbuk Umana (ORCID: https://orcid.org/0000-0002-0780-8614)
- Alejandro Lazo-langner
- Marc Blondon (ORCID: https://orcid.org/0000-0001-7032-9491)
- Marc Rodger (ORCID: https://orcid.org/0000-0001-8166-3487)
- Sam Schulman (ORCID: https://orcid.org/0000-0002-8512-9043)
- Abbey Willcox (ORCID: https://orcid.org/0000-0002-9343-542X)
- Tony Wan (ORCID: https://orcid.org/0000-0002-9820-1446)
- Deepa Suryanarayan (ORCID: https://orcid.org/0009-0004-7309-5191)
- Benoît Côté (ORCID: https://orcid.org/0000-0002-5258-0778)
- Helen Crowther
- SR Kahn
- Kerstin de Wit
- Erin Thomas
- Sudeep Shivakumar
- Jean-Philippe Galanaud
- Stefano Barco
- Gregoire Le Gal
- Peter Greenstreet
- Susan Solymoss
- James Douketis
- Michael J. Kovacs
- Lana A. Castellucci
- Erik Yeo
- Huyen A. Tran
- Lisa Baumann Kreuziger
- Clive Kearon
Institutions
- University of Bern (CH)
- Western University (CA)
- The University of Sydney (AU)
- Concord Hospital (US)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of British Columbia (CA)
- Royal College of Surgeons in Ireland (IE)
- University of Ottawa (CA)
- University of Calgary (CA)
- Johannes Gutenberg University Mainz (DE)
- Queen's University (CA)
- Concord Repatriation General Hospital (AU)
- Queen Elizabeth II Health Sciences Centre (CA)
- Hamilton General Hospital (CA)
- Austin Hospital (AU)
- Ottawa Hospital (CA)
- University Hospital of Bern (CH)
- McGill University Health Centre (CA)
- Jewish General Hospital (CA)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- The Alfred Hospital (AU)
- Blacktown & Mount Druitt Hospital (AU)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Hospital of Zurich (CH)
- Versiti Blood Center of Wisconsin (US)
- Australian Centre for HIV and Hepatitis Virology Research (AU)
- Hôpital de l'Enfant-Jésus (CA)
- Calvary Mater Newcastle Hospital (AU)
- Thrombosis and Atherosclerosis Research Institute (CA)
- American Thrombosis and Hemostasis Network (US)
- National Health and Medical Research Council (AU)
- McGill University (CA)
- Monash University (AU)
- Geneva College (US)
- McMaster University (CA)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1056/nejmoa2510703
- Citations
- 2
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 59.54