A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer
We utilize the atlas to contextualize the relationships between existing signatures and cell populations, harmonize nomenclature across studies, and show the power of this large-scale resource to robustly identify associations between transcriptional signatures and clinical phenotypes that would not be possible to discover using fewer patients. Beyond our findings, the atlas serves as a public resource for the high-resolution characterization of tumor heterogeneity of HPV-negative HNSCC.
Authors
- Lina Kroehling (ORCID: https://orcid.org/0000-0003-4996-7450)
- Anthony Spinella
- Maria A. Kukuruzinska
- Eric Reed (ORCID: https://orcid.org/0000-0003-2347-720X)
- Xaralabos Varelas (ORCID: https://orcid.org/0000-0002-2882-4541)
- Stefano Monti
- Andrew Chen
Institutions
- Boston University (US)
- Boston Medical Center (US)
- Albert Einstein College of Medicine (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1038/s43856-026-01401-3
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Clinical and Translational Science Institute, Boston University
- National Institute of Dental and Craniofacial Research
- National Center for Advancing Translational Sciences