Putative α7-selective ligands interact with α9-containing nicotinic acetylcholine receptors and modulate immune functions of human mononuclear phagocytes
Our findings provide a more nuanced framework for interpreting the roles of nAChR subtypes in non-neuronal immune modulation, highlighting the complexity and potential importance of α9* nAChRs in the context of inflammation and innate immunity. The results underscore the importance of considering the nAChR subunit α9 when developing α7-selective ligands for immunomodulation and provides novel insights into the role of α9* nAChRs as potential therapeutic targets for inflammatory diseases and pain.
Authors
- Karl N. Kirschner (ORCID: https://orcid.org/0000-0002-4581-920X)
- Hina Andleeb (ORCID: https://orcid.org/0000-0003-1992-6201)
- Katrin Richter (ORCID: https://orcid.org/0000-0002-2450-1083)
- Daria Bozic
- V Grau
- Arik J. Hone (ORCID: https://orcid.org/0000-0002-9912-0955)
- Roger L. Papke (ORCID: https://orcid.org/0000-0002-4468-8658)
- Mona Mobasher (ORCID: https://orcid.org/0009-0001-4770-3964)
- Malin Pilzecker
- Andreas Hecker
- J. Michael McIntosh
Institutions
- Concordia University Wisconsin (US)
- Hochschule Bonn-Rhein-Sieg (DE)
- Justus-Liebig-Universität Gießen (DE)
- University of Utah (US)
- Concordia University (US)
- Io Therapeutics (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-03-11
- DOI
- https://doi.org/10.3389/fimmu.2026.1773637
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- Precursory Research for Embryonic Science and Technology