Alkaloids from Evodia rutaecarpa inhibit the occurrence and development of gallbladder cancer in vivo and in vitro
This study confirms that evodiamine inhibits GBC cell proliferation and induces apoptosis. The mechanism involves suppression of ZEB1 expression and inactivation of the PI3K-Akt signaling pathway.
Authors
- Kunqi Sun
- Hanzheng Xu
- Siyang Hu
- Jiahua Yang
- Ke Xu
- Yijie Li
- Hongye Zhou
- Shufen Zhou
- Wei Li
- Yafeng Chen
Institutions
- Shanghai University (CN)
- East China University of Science and Technology (CN)
- Wenzhou Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Central Hospital of Putuo District (CN)
- Sanming University (CN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-03-13
- DOI
- https://doi.org/10.1038/s41598-026-35563-w
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- National Key Research and Development Program of China