Bioprospecting marine-derived <i>Nocardia</i> sp. SPL22-064 of the Lombok Sea exhibits potent anti-nontuberculous mycobacteria (NTM) activity

This study investigates the bioprospecting potential of marine-derived bacteria from the Lombok Sea, Indonesia, as a source of anti-nontuberculous mycobacteria (anti-NTM) agents. A total of fifty-two isolates were fermented in two different media and extracted, yielding 104 crude extracts. The bioassay-guided screening was evaluated, and the extract derived from the strain SPL22-064 exhibited the most potent activity, with a minimum inhibitory concentration (MIC) of 31.25 µg/ml against <i>Mycobacterium fortuitum</i> ATCC 6841. The strain was identified as <i>Nocardia</i> sp. Untargeted LC-HRMS-based analysis was performed to provide an overview of the chemical profile of the active extract. To our knowledge, this study represents the first report suggesting the potential of a marine-derived <i>Nocardia</i> sp. as a source of antimycobacterial agents.

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Publication Details

Journal
Natural Product Research
Published
2026-03-12
DOI
https://doi.org/10.1080/14786419.2026.2641232
Primary Topic
Actinomycetales infections and treatment
Type
article
Field-Weighted Citation Impact
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article

Bioprospecting marine-derived Nocardia sp. SPL22-064 of the Lombok Sea exhibits potent anti-nontuberculous mycobacteria (NTM) activity

Ni Luh Putu Vidya Paramita, Titik Nuryastuti, Ni Putu Ariantari, Shanti Ratnakomala et al.
Natural Product Research
Actinomycetales infections and treatment
article

Bioprospecting marine-derived Nocardia sp. SPL22-064 of the Lombok Sea exhibits potent anti-nontuberculous mycobacteria (NTM) activity

Ni Luh Putu Vidya Paramita, Titik Nuryastuti, Ni Putu Ariantari, Shanti Ratnakomala, Linda Sukmarini, Idham Sumarto Pratama, Sinta Indiarti Nurrohmah, Eni Dwi Islamiati, TRIANA HERTIANI, Muhammad Khafi, Christine Imbert, Bustanussalam, Lely Retno Wulansari, Fahrurrozi Fahrurrozi
article en

Abstract

This study investigates the bioprospecting potential of marine-derived bacteria from the Lombok Sea, Indonesia, as a source of anti-nontuberculous mycobacteria (anti-NTM) agents. A total of fifty-two isolates were fermented in two different media and extracted, yielding 104 crude extracts. The bioassay-guided screening was evaluated, and the extract derived from the strain SPL22-064 exhibited the most potent activity, with a minimum inhibitory concentration (MIC) of 31.25 µg/ml against <i>Mycobacterium fortuitum</i> ATCC 6841. The strain was identified as <i>Nocardia</i> sp. Untargeted LC-HRMS-based analysis was performed to provide an overview of the chemical profile of the active extract. To our knowledge, this study represents the first report suggesting the potential of a marine-derived <i>Nocardia</i> sp. as a source of antimycobacterial agents.

Natural Product Research
Udayana University (ID), Universitas Gadjah Mada (ID), University of Brawijaya (ID), Central Institute of Freshwater Aquaculture (IN), Institut thématique Génétique, génomique et bioinformatique (FR), Food and Drug Administration (TH), Écologie et Biologie des Interactions (FR), Campbell Collaboration (NO), National Research and Innovation Agency (ID)
Life below water
Openalex Percentile: Top 31%
Actinomycetales infections and treatment
DOISourceOpenAlex
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