Glymphatic dysfunction is associated with cognitive impairment in white matter hyperintensities: A DTI-based study
Cognitive impairment in patients with WMHs is closely linked to decreased DTI-ALPS index, especially as white matter lesions worsen. Glymphatic dysfunction may play a critical role in this cognitive impairment, positioning the DTI-ALPS index may serve as a potential biomarker for cognitive impairment in patients with WMHs.
Authors
- Baogen Du
- Gong‐Jun Ji (ORCID: https://orcid.org/0000-0002-7073-5534)
- Xingqi Wu (ORCID: https://orcid.org/0000-0003-0646-1353)
- Panpan Hu
- Chunhua Xi
- Qiang Wei
- Shanshan Cao
- Shihao Ruan
- Jun Zhang
- Wenchen Sun
- Yuanyuan Liu
- Xin Wang
- Weiqiang Li
- Jinying Yang (ORCID: https://orcid.org/0000-0002-6328-5694)
- YING ZHANG
- Kai Wang
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Wuhan Wudong Hospital (CN)
- Chuzhou University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
- Anhui Mental Health Center (CN)
Publication Details
- Journal
- IBRO Neuroscience Reports
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1016/j.ibneur.2026.03.008
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Medical University
- University of Science and Technology of China
- Anhui Provincial Department of Education