Colorectal adenoma presence is associated with decreased menaquinone pathway functions in the gut microbiome of patients undergoing routine colonoscopy
The presence of colorectal adenomas was associated with reduced microbial metabolic functions linked to vitamin K₂ biosynthesis, amino acid fermentation, and propionate production, alongside compositional shifts toward a less functionally robust gut microbiome. These findings indicate that early colorectal neoplasia is accompanied by functional microbiome alterations that may serve as markers of adenoma-associated dysbiosis and provide insight into early metabolic changes in the colonic microenvironment.
Authors
- Ivars Tolmanis (ORCID: https://orcid.org/0000-0003-0783-6460)
- Ivars Silamiķelis (ORCID: https://orcid.org/0000-0002-7932-1047)
- Laila Silamiķele (ORCID: https://orcid.org/0000-0003-2550-0434)
- Ilona Vilkoite (ORCID: https://orcid.org/0000-0001-9663-9156)
- Olga Sjomina (ORCID: https://orcid.org/0000-0002-3248-9846)
- Krista Cēbere
- Ksenija Margole
- Aivars Lejnieks
- Jānis Kloviņš
- Elīna Runce
Institutions
- Latvian Biomedical Research and Study Centre (LV)
- Riga East University Hospital (LV)
- Riga Stradiņš University (LV)
- Riga Technical College (LV)
- University of Latvia (LV)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1371/journal.pone.0344050
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Regional Development Fund